Prior studies have linked several genes (LGALS8, PTPN12, YTHDC2, APOBEC3G, GPX3, RASA3, and TSPAN4) to immune responses, highlighting the impact of the tumor microenvironment (TME) on DCIS [18,19,20,21,22,23,24]. The gene discussed is TSPAN4; the disease is ductal breast carcinoma in situ.