Prior studies have linked several genes (LGALS8, PTPN12, YTHDC2, APOBEC3G, GPX3, RASA3, and TSPAN4) to immune responses, highlighting the impact of the tumor microenvironment (TME) on DCIS [18,19,20,21,22,23,24]. Here, LGALS8 is linked to ductal breast carcinoma in situ.