MIOX and type 2 diabetes mellitus: In the studies conducted by Wang et al., MIOX was demonstrated to be a key N6-methyladenosine-regulated ferroptosis gene in patients with type 2 diabetes mellitus MIOX overexpression has been shown to promote ROS accumulation, induce lipid peroxidation, and suppress both GPX4 activity and NADPH levels, thereby exacerbating ferroptosis in pancreatic β cells [33].