A 2020 study credited JUNB (also Zinc finger protein 36 [ZFP36] and Suppressor of cytokine signaling 3 [SOCS3]) with a pivotal role in the androgen-deprivation-therapy-induced (ADT-induced) tumor immune microenvironment (TIM) remodeling and also correlated its expression to PSA recurrence-free survival (PSA-RFS) [101]. The gene discussed is SOCS3; the disease is neoplasm.