The loss of JUNB and Phosphatase and tensin homolog (PTEN) in mouse models led to highly invasive PCa, and decreased levels of cyclin-dependent kinase inhibitor 2A (CDKN2A or p16INK4a) and Cyclin-dependent kinase inhibitor 1A (CDKN1A or p21Waf1/Cip1) were documented [82] (Figure 2). Here, CDKN1A is linked to posterior cortical atrophy.