In addition, the administration of apple polyphenols to rats with streptozotocin (STZ)-induced diabetes for 10 weeks lowered their blood urea nitrogen-to-creatinine ratio and urinary albumin-to-creatinine ratio, reduced lipid peroxidation in their kidneys, and protected against diabetic nephropathy through an improvement in renal function and a reduction in oxidative stress [57]. This evidence concerns the gene ALB and diabetes mellitus.