Furthermore, it has been reported that the administration of naringin (50 mg/kg), chlorogenic acid (10 mg/kg), and quercetin (50 mg/kg) to rats with STZ-induced diabetes for 10 weeks ameliorated their renal injury and fibrosis by improving antioxidant status and reducing transforming growth factor-beta (TGF-β), tumor necrosis factor (TNFα), and p53 expression [58]. This evidence concerns the gene TGFB1 and diabetes mellitus.