SIRT1 and diabetic kidney disease: In rabbits with diabetic nephropathy, Resveratrol ameliorates renal hypoxia, mitochondrial dysfunction, and the apoptosis of renal tubular cells by activating the silent signaling regulator l (SIRT1), peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC1α), and hypoxia-inducible transcription factor 1 alpha (HIF1α) signaling pathways [21].