The development factors and cytokines TGF, HGF, SDF-1, and IL-1, which are continuously secreted by CAFs, boost the growth and spread of surrounding tumor cells and promote angiogenesis in a variety of malignancies, including breast, pancreatic, ovarian, and liver cancers, and trigger an inflammatory response that promotes tumor development. The gene discussed is CXCL12; the disease is neoplasm.