MAPT and Alzheimer disease: Although not exclusive to AD, as similar tau pathologies are present in disorders such as frontotemporal dementia, progressive supranuclear palsy, corticobasal degeneration, and Pick’s disease, it proposes that tau pathology initiates in specific brain regions, such as the entorhinal cortex or locus coeruleus (LC), and subsequently propagates through neuronal circuits to involve widespread cortical areas, ultimately resulting in neurodegeneration [10,11].