PPARGC1A and liver dysplastic nodule: Quercetin has been shown to alleviate DN by activating the AMPK (AMP-activated protein kinase)/PGC-1α (peroxisome proliferator-activated receptor gamma coactivator-1α) pathway, improving mitochondrial function, increasing nerve conduction velocity, and preserving myelin integrity in streptozotocin-induced diabetic rats [75].