In xenograft models of breast cancer, curcumin reduced tumor volume by modulating STAT3 signaling, increasing apoptotic markers (cleaved PARP, caspase-3, -7, -9, Bax, Bid) and decreasing antiapoptotic proteins (Bcl-2, Mcl-1, Bcl-xL) [161,162]. This evidence concerns the gene CASP3 and breast cancer.