In liver cancer cells exposed to palmitic acid, combined treatment with curcumin and resveratrol suppressed triglyceride accumulation and modulated PI3K/mTOR/STAT3 signaling, while inhibiting HIF-1α and VEGF expression, demonstrating the broader mechanistic impact of curcumin on tumor cell metabolism and survival [57,58]. The gene discussed is STAT3; the disease is neoplasm.