Epigenetically, PSMB9′s correlation with m1A, m5C, and m6A RNA modification genes further indicates layered regulatory control, with positive associations in cancers like PAAD and KIRC potentially facilitating immune-related mRNA stability, while negative correlations in THCA and CESC might dampen its expression to promote immune evasion. The gene discussed is PSMB9; the disease is cancer.