While proteasome components have been implicated in immune surveillance, the role of PSMB9, the key subunit of the immunoproteasome, has been studied primarily in specific contexts like NSCLC, with limited systematic analysis of its pan-cancer expression, role in orchestrating tumor immune environment, and functional relevance to immune-mediated therapies. The gene discussed is PSMB9; the disease is non-small cell lung carcinoma.