The importance of the acrosomal localization leading to successful fertilization has also been demonstrated in the case of globozoospermic patients, characterized by a defective morphology of the sperm head (round head) due to a DPY19-like 2 (DPY19L2) mutation that is a key causative factor related to human globozoospermia. Here, DPY19L2 is linked to Globozoospermia.