ANGPT2 and nasopharyngeal carcinoma: For example, an anti-angiogenetic effect of HOTAIR knockdown was observed in nasopharyngeal cancer (NPC), both in vitro and in vivo, by directly suppressing the expression and secretion of VEGF-A and Ang2 in NPC cells and animal xenograft, providing evidence that HOTAIR silencing acts as an anti-angiogenesis factor in NPC carcinogenesis [69].