PVT1 and neoplasm: Other lncRNAs may also act as transcriptional regulators involved in tumor progression in HNSCC, such as MALAT1, which modulates alternative splicing and regulates gene expression through nuclear interactions, being responsible for amplifying tumor proliferation and invasion; PVT1, which transcriptionally regulates genes involved in cell proliferation and survival; and H19, which acts as a “sponge” for microRNAs and influences the expression of some oncogenes at the transcriptional level [23].