To this end, MALAT1 induces TGF-β and STAT3 overexpression [85] and promotes the activation of Wnt/β-catenin and NF-κB pathways by suppressing VHL, a E3 ligase known to induce the degradation of β-catenin and P65 proteins to inhibit tumor progression [86]. Here, NFKB1 is linked to neoplasm.