Thus, in HNSCC, lncRNAs promote cell proliferation by activating major oncogenic pathways, such as EGFR/PI3K/AKT/mTOR, MAPK/ERK, Wnt/β-catenin, JAK/STAT3, and MYC (Figure 2). The gene discussed is EGFR; the disease is head and neck squamous cell carcinoma.