In HNSCC, it interacts with Polycomb Repressive Complex 2 (PRC2), particularly EZH2, to induce trimethylation of histone H3 at lysine 27 (H3K27me3), a repressive mark, leading to chromatin compaction and gene silencing—especially of tumor suppressor genes, such as PTEN and E-cadherin, thereby promoting proliferation, invasion, and metastasis [11]. The gene discussed is PTEN; the disease is head and neck squamous cell carcinoma.