In line with these in vitro results, xenograft experiments demonstrated that SMIM25 overexpression significantly accelerated tumor growth in vivo, with the SMIM25-overexpressing group showing a faster tumor growth rate and larger tumor volume compared to the control group (95% CI [0.0018, 0.0749]; Cohen’s d = 1.48; p < 0.05; Figure 6C and Figure S6C). This evidence concerns the gene PELATON and neoplasm.