These clusters included three CD4+ T-cell subsets (14, 16, 17), three CD8+ T-cell subsets (1, 4, 9), three CD45RA+ cell subsets (2, 3, 6), one B-cell subset (7), two Treg subsets (13, 15), one macrophage subset (11), one tumor-associated neutrophil subset (10), one monocyte subset (12), and two unknown T-cell subsets (5,8) (Figure 5A,B). This evidence concerns the gene CD8A and neoplasm.