Subsequent studies focused on the possibility of generation by CYP4Z1 of arachidonic acid metabolites such as pro-angiogenic epoxyeicosatrienoic acids (EETs) and HETE acids, considered critical modulators of cancer progression, acting in concert with the endothelial growth factor and other growth factors, ultimately promoting cellular proliferation, neovascularization, angiogenesis, and metastasis. The gene discussed is CYP4Z1; the disease is cancer.