HIF1α, which transcriptionally induces vascular endothelial growth factor (VEGF) to promote angiogenesis,[6] upregulates glucose transporter 1 (GLUT1),[7] and upregulates glycolytic and pentose phosphate pathway (PPP) enzymes, is currently considered as a central driver of cancer metabolic reprogramming. The gene discussed is HIF1A; the disease is cancer.