Consistent with these bone regenerative effects, enzyme‐linked immunosorbent assays (ELISAs) showed that periodontitis sharply elevated pro‐inflammatory cytokines (TNF‐α, IL‐1β, IL‐6), whereas HIPPE and HIPPE‐QU treatment significantly reduced their levels, with HIPPE‐QU‐750 nearly restoring cytokine concentrations to normal (Figure 9g–i). Here, IL1B is linked to periodontitis.