Building on previous findings that HIF‐1 signaling played a pivotal role in the metabolic reprogramming of macrophages in periodontitis (Figure 1c–i), GSEA and heatmap analyses further demonstrated significant downregulation of glycolysis‐related genes, including hexokinase (HK)1/2, pyruvate kinase M 2 (Pkm2), and glucose transporter 1 (Glut1) in the HIPPE‐QU‐treated group (Figure 6e,g; Figure S4d, Supporting Information). This evidence concerns the gene HK1 and periodontitis.