HIF1A and periodontitis: During the progression of periodontitis, the regulation of macrophage polarization plays a critical role, characterized by markedly enhanced macrophage glycolysis and ATP metabolism that are partly mediated by the HIF‐1 signaling pathway.[26] Targeting this immune imbalance, we developed a multifunctional injectable HIPPE‐QU platform that achieves comprehensive treatment of periodontitis lesions by metabolically reprogramming macrophages and promoting tissue regeneration.