HAVCR1 and hepatocellular carcinoma: While this association was observed in human cohorts, TIM1 did not play a role in entry into Huh-7.5 human hepatoma cells and mice lacking IFNAR1/TIM1 or IFNAR1/TIM4 remained susceptible to HAV infection and disease (42), suggesting TIM1 may play a limited role in HAV-induced disease.