BRCA1 and breast carcinoma: Xeroderma pigmentosum (XP), a condition characterized by impaired DNArepair, leads to pigmentation in sun-exposed skin areas and significantly increasesthe risk of skin cancer (Fayyad et al., 2020).In a study conducted by Sylwia Pietrasik, the hypothesis was proposed that theinteraction between BRCA1 and GADD45 can lead to the over-repair of DNA damage,thereby increasing the risk of breast cancer (Pietrasik et al., 2020).