Specifically, NIPAL1 was found to be adversely associatedwith metastasis and cell cycle (Figure 5 c), while ZYG11B showed a positive correlation with EMT and a negativecorrelation with invasion (Figure 5 d ).These findings suggest that the presence of NIPAL1 and ZYG11B may have apreventive effect on tumor progression, including invasion and metastasis.Furthermore, ZYG11B may exhibit dual roles in CRC tumorigenesis, promoting thetransformation of normal cells into tumor cells in the early stages andinhibiting tumor progression in the late stages. This evidence concerns the gene ZYG11B and colorectal carcinoma.