PIEZO1 and neoplasm: Since a large number of studies have revealed that cells sense the biophysical properties in TME through mechanosensors such as integrins and Piezo1, it has been suggested that the regulation of mechano‐responsiveness in immune cells may represent a promising strategy for anti‐tumor therapy.[184, 185] For instance, the inhibition of Piezo1 in myeloid cells could suppress tumor development.[186] The YAP/TAZ signaling pathway performed as an emerging mechanotransducer in elaborating tumor cells‐immune cells interactions.[187] Ni et al.