TGFB1 and renal fibrosis: discovered that the intensity of TGF‐β signaling contributed to determine the differentiation of M2a and M2c subtypes in renal fibrosis.[206] In renal fibrosis, M2a macrophages exacerbated the progression of renal fibrosis by transforming into myofibroblasts; conversely, M2c macrophages exerted anti‐inflammatory effects and alleviated the degree of fibrosis.