PIEZO1 and pulmonary fibrosis: discovered that the deficiency of IL‐24 in mice could significantly decreased TGF‐β production in the lung, leading to less M2 macrophage infiltration and relieving the lung fibrosis.[208] As an acknowledged mechanosensor on macrophages, Piezo1 was detected upregulated in human and murine fibrotic liver samples.[209] Mechanically, the activation of Piezo1 enhanced macrophages inflammatory response and increased the secretion of cathepsin S (CTSS), an important lysosomal protease in ECM remodeling), thus promoting fibrosis development (Figure 7D).