Piezo1 was demonstrated to mediate the of mechanotransduction DCs and direct the mutual differentiation of Th1 and Treg cells in cancer, that is, deletion of Piezo1 in DCs inhibited the generation of Th1 cells while enhanced the development of Treg cells.[137] With their tailored and bio‐friendly mechanics, hydrogels have become a promising biomaterial for T cell activation. Here, PIEZO1 is linked to cancer.