MAPT and Alzheimer disease: It is also involved in the phosphorylation of the amyloid precursor protein (APP) at Thr668, leading to the proteolytic cleavage that results in the production of amyloid‐β peptide (Aβ).[11, 12] Notably, p‐Tau (forming neurofibrillary tangles) and Aβ (forming amyloid plaques) are the two main molecular hallmarks of AD.