For in vitro studies, we exploited the experimental paradigm of tau hyperphosphorylation induced by Herpes Simplex virus type 1 infection.[13] SH‐SY5Y human neuroblastoma cells were thus infected or not with HSV‐1 and treated with a‐LiG‐AuNPs used at 0.05 and 1 mg/mL for 24 h, then fixed in formalin solution 10% and finally processed for IF. This evidence concerns the gene MAPT and neuroblastoma.