The plasma concentrations of SIRT1 were shown to be lower in individuals with lymph node metastases compared to those without lymph node metastases [(2.67 ± 1.36) ng/mL vs. (3.74 ± 1.19) ng/mL, p = 0.001]. The gene discussed is SIRT1; the disease is metastatic malignant neoplasm in the lymph nodes.