The quantities of SIRT1 in the plasma of patients diagnosed with colon cancer exhibited a noteworthy distinction between the low and moderately differentiated groups, as well as the highly differentiated group [(2.48 ± 1.14) ng/mL vs. (3.69 ± 1.40) ng/mL, p < 0.01]. This evidence concerns the gene SIRT1 and malignant colon neoplasm.