In specific, they used Olink's proximity extension assay (PEA) for measurement of five blood protein markers, including amphiregulin, and obtained an area under the curve (AUC) of 0.82 for all CRC stages (n = 56), 0.86 for early stage CRC (n = 23) and 0.60 for AA (n = 101), showing promising results to be tested in larger clinical validation studies. The gene discussed is AREG; the disease is colorectal carcinoma.