Wy14643, an agonist of PPARA receptors, has been studied for its effects on autophagy by Luo et al. both in vitro in human microglia (HM) cells and U251 human glioma cells expressing mutant APP‐p.M671L and in vivo in APP‐PSEN1ΔE9 mice. This evidence concerns the gene APP and glioma.