We aimed to exploit the disruptive effects on NPCs to disrupt highly aggressive NSCLC cells, wherein we recently demonstrated the crucial roles NPCs and their upregulation play in the malignant transformation of cells.17 Indeed, aggressive cancer cells are substantially more sensitive to NPC inhibition, as recently demonstrated by Sakuma et al.,18 who showed that inhibition of NPC formation selectively induces cancer cell death. Here, NPC1 is linked to cancer.