TNF and colorectal carcinoma: These findings support our investigation of the TaqI polymorphism in the VDR gene and CRC risk by showing that VDR signaling modulates intestinal inflammation via the TNF-α pathway. Since chronic inflammation like IBD is a known CRC risk factor, variations in VDR, such as TaqI, may influence individual CRC susceptibility. The animal model highlights VDR’s protective role and the plausibility of its genetic impact on CRC.