TNF and adult T-cell leukemia/lymphoma: Higher plasma levels of TNF-α and IL-6 cytokines, and CXCL10 are found in patients with aggressive ATLL when compared to those with indolent ATLL (aka. stable and slow growing form of lymphoma/leukemia usually associated with lesser fever and lesser symptoms), indicating a worsening role of strong inflammatory responses in ATLL disease severity (74, 107).