Finally, Tax- and HBZ-transgenic mice, which develop HTLV-1-like impairments such as T-cell lymphoma and systemic inflammation, display higher production of TNF-α and IFN-γ in FoxP3+ splenocytes, and of IL-1α/β and IL-6 in ATLL-like cells (112–114). The gene discussed is FOXP3; the disease is adult T-cell leukemia/lymphoma.