IFNG and Hemophagocytosis: Activated immune cells have been established to release proinflammatory cytokines (IFN-γ, TNF-α, IL-1, IL-6, TNF-α, and so on), leading to high levels of macrophage activation, which, in turn, might cause hemophagocytosis, tissue damage, organ failure, and other inflammatory manifestations (23, 24).