Activated immune cells have been established to release proinflammatory cytokines (IFN-γ, TNF-α, IL-1, IL-6, TNF-α, and so on), leading to high levels of macrophage activation, which, in turn, might cause hemophagocytosis, tissue damage, organ failure, and other inflammatory manifestations (23, 24). This evidence concerns the gene TNF and Hemophagocytosis.