Activated immune cells have been established to release proinflammatory cytokines (IFN-γ, TNF-α, IL-1, IL-6, TNF-α, and so on), leading to high levels of macrophage activation, which, in turn, might cause hemophagocytosis, tissue damage, organ failure, and other inflammatory manifestations (23, 24). The gene discussed is IL6; the disease is Hemophagocytosis.