Furthermore, the pattern of inflammatory cytokines (IFN-γ and IL-10 upregulation, with only modestly elevated IL-6 levels) demonstrated a high diagnostic accuracy for secondary hemophagocytic lymphohistiocytosis secondary hemophagocytic lymphohistiocytosis (sHLH) and could be useful in differentiating infection-induced HLH and monitoring patients (27). This evidence concerns the gene IFNG and infection.