HIF1A and rheumatoid arthritis: Coix seeds, the main component of YYRT, contain coix seed ester and polysaccharide components, which can exert anti-RA effects by reducing the levels of proinflammatory cytokines (IL-1β, TNF-α, IL-6, and MCP-1), alleviating oxidative stress (30), and alleviating synovial angiogenesis by suppressing the HIF-1α/VEGF-A signaling pathway (31).