It has anti-RA effects by targeting multiple pathways (18), such as regulating neurotransmitters (19); adjusting macrophages and the levels of inflammatory cytokines (20); decreasing the mRNA and protein levels of p-NF-κB and IL-17 (21); reducing inflammation in fibroblast-like synoviocytes (22); and synergistically targeting the cAMP, PI3K/Akt, and HIF-1α pathways (23). This evidence concerns the gene HIF1A and rheumatoid arthritis.