However, this has resulted in ROP becoming a major cause of childhood blindness worldwide.1, 2, 3 Retinopathy of prematurity is caused by oxygen-induced damage to the developing retinal vasculature, which leads to hyperoxia-induced vascular obliteration and abnormal growth of retinal blood vessels mediated by VEGF, insulin-like growth factor I, and other signaling pathways.4 Here, IGF1 is linked to retinopathy of prematurity.