IDH3A and central nervous system cancer: Despite these limitations, the results of our novel method to study functional reorganization are consistent with a growing body of evidence demonstrating that gliomas can induce changes in FC in distal regions, including the contralateral hemisphere1,4,9,12,14,16,76 and highlights the significance of isocitrate dehydrogenase mutation when considering the potential for functional reorganization in glioma patients.