This is in line with previous research showing significant structural and functional brain-wide changes in IDH-mutant gliomas.8,11,74 For example, Huang and colleagues found that contralesional macrostructural plasticity is observed in left insular IDH-mutant gliomas but had no association with histological grade, 1p19q co-deletion, or TERT promoter mutation.8 Notably, our relatively small sample size restricts our ability to draw conclusive insights about the differential impact of IDH mutation and WHO grade on the contralesional connectome. Here, TERT is linked to central nervous system cancer.