For instance, a recent study demonstrated the modulatory role of thrombospondin-1, a synaptogenic factor, on the functional remodeling of neural circuits induced by glioma.2 While the techniques utilized herein do not elucidate the underlying molecular mechanisms that contribute to functional reorganization, our findings are in line with the general hypothesis that functional changes in the contralesional hemisphere depend in part on factors such as tumor location and molecular markers. Here, THBS1 is linked to central nervous system cancer.