EIF2AK3 and neoplasm: Furthermore, it has been observed that protein kinase RNA‐like endoplasmic reticulum kinase (PERK), a molecule associated with the unfolded protein response (UPR) that is highly expressed in tumor‐infiltrating MDSCs, can inhibit STING‐mediated type I interferon responses and enhance its immunosuppressive function by maintaining mitochondrial homeostasis [61].