GZMB and neoplasm: Notably, treatment of Ch25hf/fLyz2Cre(±) mice injected with C176 resulted in a marked suppression of the antitumor effect, further accelerating tumor progression, increasing ARG1 expression, and leading to a significant reduction in CD8+ TILs and IFNγ+ or GzmB+ CD8+ TILs compared to those injected with the vector control (Figure 7G–L).