Genetic evidence from Drosophila and murine models confirms CDGI's role in LRRK2‐dependent neurodegeneration: (1) progressive retinal degeneration in flies, and (2) striatal dopaminergic neuron loss with motor deficits in mice—phenotypes abolished in LRRK2‐null backgrounds, demonstrating strict LRRK2 dependence [248]. Here, LRRK2 is linked to retinal degeneration.