In colorectal cancer (CRC), the m6A reader YTHDF1 amplifies GEF–H1 translation to constitutively activate RhoA, while hypoxia‐induced exosomal circ‐133 sponges miR‐133a to relieve GEF–H1 inhibition [219, 228]. This evidence concerns the gene ARHGEF2 and colorectal carcinoma.