SIRT1 and urogenital neoplasm: Current evidence suggests that quercetin exerts nephroprotective effects through multiple mechanisms: it increases renal Bcl-2 levels, inhibits CHOP mRNA expression, and attenuates ERS and apoptosis through sirtuin 1 (SIRT1)-dependent deacetylation, thus effectively attenuating cadmium chloride-induced kidney injury in rats.