It can mediate the myocardial protective effect of PGC-1α and can also work with AMPK to maintain energy homeostasis, protect cardiomyocytes from oxidative damage and aging, and inhibit cardiac hypertrophy (Afzaal et al., 2022; Silaghi et al., 2021; Xin and Lu, 2020). The gene discussed is PPARGC1A; the disease is cardiac hypertrophy.