Our results suggested that DC could induce HT-29 and HCT-116 cell apoptosis through upregulation of Bax and downregulation of Bcl-2 expression and activation of the caspase-3 pathway in HT-29 and HCT-116 cells, suggesting that apoptosis induction could play an important role for DC-mediated anti-proliferation of colon tumor cells. The gene discussed is BCL2; the disease is colonic neoplasm.