Curcumin dose-dependently downregulates the expression of EphA2, PI3K, and MMP2 to block the EphA2/PI3K/MMP-2 signaling pathway, thereby suppressing ECM remodeling as well as glioblastoma cell migration and invasion, ultimately disrupting VM formation in glioblastoma (Liang et al., 2014). This evidence concerns the gene MMP2 and glioblastoma.