This results in the downregulation of VE-cadherin, p-AKT, MMP2, and laminin γ2 (LAMC2), thereby forming an EphA2/Twist–VE-cadherin/AKT/MMP2/LAMC2 signaling cascade that ultimately inhibits VM formation in PCa PC-3 cells (Han et al., 2022). Here, AKT1 is linked to posterior cortical atrophy.