PIK3CD and glioblastoma: Curcumin dose-dependently downregulates the expression of EphA2, PI3K, and MMP2 to block the EphA2/PI3K/MMP-2 signaling pathway, thereby suppressing ECM remodeling as well as glioblastoma cell migration and invasion, ultimately disrupting VM formation in glioblastoma (Liang et al., 2014).