This effect is achieved through the downregulation of VM-related markers including VE-cadherin, N-cadherin, Vimentin, Snail, and MMP9, along with the upregulation of E-cadherin, thereby interfering with EMT and ECM remodeling processes associated with VM formation in lung cancer (Lin et al., 2023). The gene discussed is CDH5; the disease is lung carcinoma.