Daurisoline (DS), an isoquinoline alkaloid derived from the TCM plant Rhizoma Menispermi, inhibits VM in HCC by directly suppressing the GTP-binding activity of RhoA, downregulating the expression of ROCK2, and inhibiting ROCK2-mediated phosphorylation of MYPT-1 and MLC-2. Here, ROCK2 is linked to hepatocellular carcinoma.