Tumor cells enhance the phosphorylation of VE-Cadherin at the Y658 residue, which promotes the formation of a VE-Cadherin/β-catenin complex and increases the transcriptional activity of TCF-4 (Delgado-Bellido et al., 2020; Delgado-Bellido et al., 2023b). Here, TCF4 is linked to neoplasm.