This activation suppresses the expression of VE-cadherin, N-cadherin, SLC7A11, and GSH, while upregulating E-cadherin, reactive oxygen species (ROS), and malondialdehyde (MDA), thereby reversing EMT and inducing ferroptosis to exert its inhibitory effects on VM in HCC. The gene discussed is CDH5; the disease is hepatocellular carcinoma.