Qilan Capsules have been found to inhibit VM tube formation in PC-3 cells of PCa by downregulating HIF-1α expression, suppressing VEGFα transcriptional activation, and reducing MMP1 activity, thus targeting the HIF-1α/VEGFα/MMP-1 signaling axis (Yu et al., 2018). This evidence concerns the gene VEGFA and posterior cortical atrophy.