This effect may be achieved by inhibiting the VEGF-mediated ERK-NFκB-cMyc-p21 signaling axis and EMT-related factors, thereby interfering with the functional expression of key VM proteins VE-cadherin and EphA2, ultimately blocking the VM process in PCa cells (Luo et al., 2012; Wang et al., 2018; Yeo et al., 2019). Here, CDH5 is linked to posterior cortical atrophy.