This further disrupts F-actin remodeling and suppresses the activities of MMP2, MMP14, and the cleavage of Ln5γ2, demonstrating the inhibition of VM in osteosarcoma cells by targeting the miR-520d-3p/MIG-7/PI3K/MMPs/Ln5γ2 signaling axis (Yao et al., 2022). Here, MMP2 is linked to osteosarcoma.