FAS and breast carcinoma: In breast cancer cell line MCF-7-MEK5 with stably EMT property, FAS was able to regulate the sensitivity of tumor necrosis factor-α (TNF-α) through modulating TNF receptor 2 (TNFR2) via lipid rafts and activating Wnt-1/β-catenin signaling pathway that closely involves in EMT (Li et al., 2014b).