CD8A and hepatocellular carcinoma: M2-polarized TAMs potentiate HCC progression and ICI resistance through protumorigenic secretomes and T cell suppression[92], whereas TAM-derived extracellular vesicles deliver the circPETH-encoded circPETH-147aa protein, which enhances tumor glycolysis via PKM2-mediated ALDOA-S36 phosphorylation and induces CD8+ T cell exhaustion through HuR-dependent methionine/leucine deprivation[93].