HLA-G interacts with immunoglobulin-like transcript 2/4 and killer cell immunoglobulin-like receptor 2DL4, inhibiting cytotoxic T cells and NK cells, while activating immunosuppressive cells such as Tregs and MDSCs, thereby creating an immunosuppressive microenvironment that facilitates tumor immune evasion[100]. Here, HLA-G is linked to neoplasm.