Since PI3K-AKT signaling is critical for cancer cell proliferation, survival, and signal transduction, inhibition of AKT phosphorylation with the inhibitor MK-2206 restored JTC801 sensitivity [Figure 2B-D, Supplementary Figure 2B and C], but did not significantly affect cryptotanshinone sensitivity in SW1990 cells [Supplementary Figure 2D]. This evidence concerns the gene AKT1 and cancer.