PIK3CA and cancer: TP53 mutations were the most prevalent cancer-related genomic alterations (64.6%), followed by nine genes with mutation frequencies ≥ 5%: PIK3CA (35.0%), BRCA2 (9.8%), KMT2C (6.5%), MAP3K1 (6.1%), OBSCN (6.1%), FLG (5.7%), FAT1 (5.7%), GATA3 (5.7%) and NEB (5.3%) [Figure 2A].