HBB and Schnyder corneal dystrophy: Although there is no published evidence supporting a predisposition to WT in a patient with HBB mutation, it is plausible that, in rare cases, the close proximity of the HBB gene and WT-related loci may reflect a shared susceptibility region on 11p15.5, on which genetic or epigenetic disruptions could contribute to the coexistence of SCD and WT [16].