NUP214 and Alzheimer disease: Of note is that prolonged CaN-NFAT activation induces the same pattern of dystrophic neurites and dendritic spine loss as Aβ both in vitro and in vivo (Wu et al., 2010) and has been used as a marker for chronic depolarization linked with cognitive decline in AD (Abdul et al., 2009; Hopp et al., 2018; Lara Aparicio et al., 2022).