Although other factors linked with neurodegeneration can also provoke CaN and NFAT activation (Cardoso and Oliveira, 2005; Reese and Taglialatela, 2011; Norris, 2018), our results suggest that engagement of convergent signaling pathways by STX protects against the loss of neuronal Ca2+ homeostasis, which is a hallmark feature of AD pathology (Berridge, 2010; Swerdlow et al., 2014; Wang et al., 2025). The gene discussed is NUP214; the disease is Alzheimer disease.