High PD-L1 expression is associated with greater aggressiveness and invasiveness of glioblastoma cells and tumors with mesenchymal features seem to have increased PD-L1 levels and higher percentages of tumor-associated macrophages.16 Therefore, accurate measurement of PD-L1 expression seems critical for identifying/selecting patients suitable for anti-PD-(L)1 treatments. This evidence concerns the gene CD274 and glioblastoma.