These associations were statistically mediated by IL-6 (12 % (p-valueFDR = 0.012) of the association with CVD, 17 % T2DM (p-valueFDR<0.001), 18 % hypertension (p-valueFDR<0.001), and 29 % obesity (p-valueFDR = 0.005)). This evidence concerns the gene IL6 and obesity due to melanocortin 4 receptor deficiency.