BIRC3 and colorectal carcinoma: BBR induces CRC cell apoptosis in a concentration-dependent manner by promoting the activation of pro-apoptotic genes such as nonsteroidal anti-inflammatory drug-activated gene-1, activating transcription factor 3, c-inhibitor of apoptosis proteins 1 (IAP1), c-IAP2, surviving, and B-cell lymphoma-extra large (Bcl-xL) (Yu et al., 2014; Piyanuch et al., 2007; Wu et al., 2012).