In addition, in recent years, membrane-associated protein (Annexin-A1) (Guo et al., 2013), a widely distributed calcium-dependent phospholipid-binding protein, has been found to act as a regulator of Wnt/β-catenin and a key growth stimulator of CRC (Rubinstein et al., 2019). Here, ANXA1 is linked to colorectal carcinoma.