In addition to the primary oral-digestive tract pathway (Kostic et al., 2013), the enrichment of Fn in CRC tissue may also be targeted to cancer colonies via a bloodborne pathway, such as transient bacteremia caused by dental surgery or periodontitis (Bullman et al., 2017; Yang and Shamsuddin, 1996). This evidence concerns the gene FN1 and colorectal carcinoma.