MAPT and Alzheimer disease: However, recent studies linking resting-state EEG α rhythms with CSF tau biomarkers reported significantly decreased α source activity in parietal, temporal, and occipital regions in AD-MCI compared to healthy controls and non-AD MCI groups, showing strong negative correlations between CSF phosphorylated tau/total tau levels and posterior α source activity, with weaker correlations to amyloid-β42 levels (Seidu et al., 2024).