In aOPCs from postmortem Alzheimer’s disease brains, the presence of the apolipoprotein ε4 allele (APOE4, a genetic risk factor for Alzheimer’s disease) is associated with impaired pro-inflammatory and immune-related pathways, altered DNA damage responses, abnormal lipid storage, and decreased myelination ability (Yi et al., 2023; Blanchard et al., 2024). This evidence concerns the gene APOE and early-onset autosomal dominant Alzheimer disease.