PIEZO1 and atherosclerosis: Further extending the role of Piezo1 in neutrophil function, a study exploring atherosclerosis in ApoE−/− mice found that low shear stress (LSS) in carotid arteries paradoxically downregulated PIEZO1 expression, causing reduced Ca2+ influx, increased HDAC2 activity, enhanced ROS, and increased NETosis, leading to endothelial apoptosis and aggravated plaque progression.15