Similarly, in critically ill adult populations following surgery, biomarker-based risk stratification using the product of urinary tissue inhibitor of metalloproteinases-2 and insulin-like growth factor binding protein 7 ([TIMP2]●[IGFBP7]) to guide the implementation of standardized AKI care bundles reduced the frequency and severity of AKI compared to standard care [13, 14]. Here, TIMP2 is linked to acute kidney injury.