Despite retaining kisspeptin expression in the hypothalamus, responsiveness to GnRH at the pituitary level, and the capacity for ovulation following gonadotropin stimulation, female mice lacking PGR in kisspeptin neurons gradually lost estrous cyclicity, failed to generate an LH surge in response to rising estradiol, and ultimately became infertile. The gene discussed is KISS1; the disease is Infertility.