Women carrying inherited mtDNA mutations have been reported to exhibit features consistent with premature ovarian insufficiency (POI), including reduced antral follicle counts, elevated follicle-stimulating hormone (FSH) levels, and lower anti-Müllerian hormone (AMH) concentrations - biomarkers indicative of diminished ovarian reserve (90, 131). The gene discussed is BRD2; the disease is Premature ovarian insufficiency.